picture of David Nesbitt
Professor Adjoint • Professor Adjunct • Institute Fellow, JILA
Chemistry • Physics • Joint Institute for Laboratory Astrophysics (JILA)
djn@jila.colorado.edu
303-492-8857

Office: JILA A805
Lab: JILA B212, B214, B217, B219, B221, X120
Lab Phone: 303-492-1453,303-492-1454, 303-735-5825, 303-735-6172, 303-492-7777, 303-492-6409
Fax: 303-735-1424
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Education

Ph.D.:听University of Colorado, 1981
Postdoctoral Fellow:听National Research Fellow at National Bureau of Standards, 1981-82

Areas of Expertise

Physical Chemistry, Chemical Physics, Spectroscopy, Atmospheric Chemistry, Astrochemistry, Biophysics, Interfaces, Nanomaterials

Awards and Honors

Fellow, American Academy of Arts and Sciences, 2013; Fellow, American Chemistry Society, 2010; Presidential Rank Award, Department of Commerce, 2009; Fellow, Royal Society of Chemistry (UK), 2005; NIST Fellow, National Institute of Standards and Technology, 2005; Bourke Medal, Royal Society of Chemistry, Faraday Division, 2002; Alexander von Humboldt Fellowship, 1999; William F. Meggers Award, Optical Society of America, 1999; Earle K. Plyler Prize, 1997; Edward Uhler Condon Award, 1995; Department of Commerce Silver Medal, 1992; Arthur S. Fleming Award, 1991; Fellow, American Physical Society, 1991; Wilson Prize Lecture (Harvard University) , 1989; Alfred P. Sloan Fellow, 1987; Dreyfus Foundation Grant for Newly Appointed Faculty in Chemistry, 1984; ACS Nobel Laureate Signature Award, 1983

Laser Studies of Spectroscopy, Reaction Dynamics and Single Molecule Microscopy: Chemical Physics, Nanomaterials and Biophysics

The Nesbitt Laboratory pursues research in four main areas:

The group's work involves extensive use of state-of-the art cw and ultrafast pulsed laser technology, nonlinear generation of tunable mid and near-infrared laser light, fast analog electronics, scan probe methods, confocal microscopy, servo-loop control, shaped supersonic expansions, plasma discharges, kinetic analysis and ab initio quantum theoretical calculations. A central unifying goal of the research program is the elucidation of fundamental kinetics and dynamics of elementary chemical/biophysical processes from both experimental and theoretical perspectives.

Professor Nesbitt is a听, a听Physicist at the National Institute of Standards and Technology (), a Full Professor in the听听and a Lecturer in the听.

N. F. Dupuis, E. D. Holmstrom and D. J. Nesbitt, 鈥淢olecular crowding effects on single molecule RNA folding/unfolding thermodynamics and kinetics,鈥� Proc. Nat. Acad. Sci, 111, 8464-8469, 听(2014).

E. D. Holmstrom and D. J. Nesbitt, 鈥淪ingle-molecule fluorescence resonance energy transfer studies of the human telomerase RNA psuedoknot: Temperature/urea dependent folding kinetics and thermodynamics,鈥� J. Phys. Chem. B 118, 3853-3863, (2014).

E. D. Holmstrom, J. T. Polaski, R. T. Batey, and D. J. Nesbitt, 鈥淪ingle-molecule conformational dynamics of a biologically functional hydroxocobalamin riboswitch,鈥� J. Am. Chem. Soc. 136, 16832-16843 (2014).

Y. Liu, E. Holmstrom, J. Zhang, P. Yu, J. Wang, M. A. Dyba, D. Chen, J. Ying, S. Lockett, D. J. Nesbitt, A. Ferre-D鈥橝mare, R. Sousa, J. R. Stagno, and Y.-X. Wang, 鈥淪ynthesis and applications of RNAs with position-selective labelling and mosaic composition,鈥� Nature听522, 368-372, (2015)

E. D. Holmstrom, N. F. Dupuis, and D. J. Nesbitt, 鈥淜inetic and thermodynamic origins of osmolyte-influenced nucleic acid folding,鈥� J. Phys. Chem. B. 119, 3687鈥�3696, (2015)

C.-H. Chang and D. J. Nesbitt, 鈥淪pectroscopy and dynamics of jet cooled polyynes in a slit supersonic discharge: Sub-Doppler infrared studies of diacetylene HCCCCH,鈥� J. Phys. Chem. A. 119, 7040 -7950, DOI:10.1021/acs.jpca.5b02310 (2015).

C.-H. Chang and D. J. Nesbitt, 鈥淪ub-Doppler Infrared Spectroscopy of Propargyl

Radical (H2CCCH) in a Slit Supersonic Expansion,鈥� 142, 244313, (2015).

E. D. Holmstrom and D. J. Nesbitt, 鈥淏iophysical Insights from Temperature-Dependent Single-Molecule F枚rster Resonance Energy Transfer,鈥� Ann. Rev. Phys.Chem.67, 1-747, (2016).

C.-H. Chang, J. Agarwal, W. D. Allen, and D. J. Nesbitt, 鈥淪ub-Doppler infrared spectroscopy and reaction dynamics of triacetylene in a slit supersonic expansion,鈥� J. Chem. Phys. 144, 074301, (2016)

J. T. Polaski, E. D. Holmstrom, D. J. Nesbitt, and R. T. Batey, 鈥淢echanistic Insights into Cofactor-Dependent Coupling of RNA Folding and mRNA Transcription/Translation by a Cobalamin Riboswitch,鈥� Cell Reports 15, 1100-1110, (2016).

A.听 L. Efros and D. J. Nesbitt, Nature Nanotech. 11, 661-671, (2016).

C. H. Hoffman and D. J. Nesbitt, 鈥淨uantum State Resolved 3D Velocity Map Imaging of Surface-Scattered Molecules: Incident Energy Effects in HCl + Self-Assembled Monolayer Collisions,鈥� J. Phys. Chem. C. 120, 16687鈥�16698, DOI: 10.1021/acs.jpcc.6b03973 (2016).

A. Sengupta, H.-L. Sung and D. J. Nesbitt, 鈥淎mino Acid Specific Effects on RNA Tertiary Interactions: Single-Molecule Kinetic and Thermodynamic Studies,鈥� J. Phys. Chem. B 120, 10615-10627, (2016).

A. Zutz and D. J. Nesbitt, 鈥淎ngle-Resolved Molecular Beam Scattering of NO at the Gas- Liquid Interface,鈥� J. Chem. Phys. 147, 054704 (2017).

M. P. Ziemkiewicz, C. Pluetzer, J. Loreau, A. van听 der Avoird, and D. J. Nesbitt, 鈥淣uclear Spin/Parity Dependent Spectroscopy and Predissociation Dynamics in vOH = 2 <鈥� 0 Overtone Excited Ne-H2O clusters: Theory and Experiment,鈥� J. Chem. Phys. (2017).

A. Kortyna, A. J. Samin, T. A. Miller and D. J. Nesbitt 鈥淪ub-Doppler infrared spectroscopy of resonance-stabilized hydrocarbon intermediates: 谓3 (b2) and 谓4 (a1) CH stretch modes and CH2 rotor tunneling dynamics of benzyl radical,鈥� Phys. Chem. Chem. Phys. 19, 29812-298821 (2017).

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