research
- Jen Leight showed spatially resolved cellularly MMP activity through a FRET reporter peptide. She showed increased MMP expression in response to TGF-beta and higher substrate modulus. This is an excellent follow-up to her June Employee of the
- Sarah Gould published a rad review of the role of matrix elasticity in aortic cell disease in Circulation Research. Congratulations Sarah!S.T. Gould, S. Srigunapalan, C.A. Simmons, and K.S. Anseth, "Hemodynamic and Cellular Response
- Katie described the advantages of photolabile hydrogel platforms in an MRS Bulletin celebrating Kristi's mid-career award.K.J.R. Lewis and K.S. Anseth, "Hydrogel Scaffolds to Study Cell Biology in Four Dimensions," MRS Bulletin, 38 (3), 260-268
- Danny Alge showed hydrogels could be formed using the bioorthogonal tetrazine-norbornene reaction. The synthetic accessibility of these chemistries will open new doors for the design of cell instructive materials.D.A. Alge, M.A. Azagarsamy, D.F.
- Chris Koehler (Bowman Lab) and Danny Alge show tunable, sustainable release of dexamethasone to induce hMSC osteogenesis using Diels-Alder chemistry.K.C. Koehler, D.A. Alge, K.S. Anseth, and C.N. Bowman, "A Diels-Alder Modulated
- Kyle Kyburz demonstrated the importance of adhesive ligand interactions and network crosslinking density on hMSC migration and spreading.K.A. Kyburz and K.S. Anseth, "Three-dimensional hMSC motility within peptide-functionalized PEG-based
- Daniel McKinnon demonstrated the 3D culture of motor neurons in engineered PEG hydrogels that enabled good viability and robust axon extention. He further demonstrated the importance of ECM-mimic peptides to the viability of dissociated cells
- Chelsea Kirschner publishes a nice review of dynamic hydrogel environments titled "Hydrogels in Healthcare: From Static to Dynamic Microenvironments" in Acta Materialia. She summarized current progress in light, enxyme, electric field,
- Malar Azagarsamy wrote an fantastic review of bioorthogonal click chemistry covering thiol-ene, click, and Michael addtions.M.A Azagarsamy and K.S. Anseth, "Bioorthogonal Click Chemistry: An Indispensable Tool to Create Multifaceted Cell
- Kelly Schultz showed that thiol-ene step-growth hydrogels degrade homogeneously when exposed to enzymes.K.M. Schultz and K.S. Anseth, "Monitoring Degradation of Matrix Metalloproteinases-Cleavable PEG Hydrogels via Multiple Particle