research
- Chun Yang showed controlled release of Dexamethasone led to osteogenic differentiation of human mesenchymal stem cells.C. Yang, P.D. Mariner, J.N. Nahreini, and K.S. Anseth, "Cell-Mediated Delivery of Glutocorticoids from Thiol-Ene
- Mark just published a perspicacious perspective on 4D cellular microenvironments in Science Translational Medicine. Reprint is available here.M.W. Tibbitt and K.S. Anseth, "Dynamic Microenvironments: The Fourth Dimension,"
- Nava showed that the osteogenic differentiation of hMSCs in hydrogels functionalized with phosphate groups can be attributed to serum protein adsorption.N.R. Gandavarapu, P.D. Mariner, M.P. Schwartz, and K.S. Anseth, "Extracellular Matrix
- April, now an assistant professor at University of Delaware, and Katie presented a dynamic culture platform in which microwells are patterned and later connected through cytocompatible photocleavage of a poly(ethylene glycol)-based
- Chelsea demonstrated that human Mesenchymal Stem Cells align along topographies patterned on the surface of photodegradable hydrogels. She further showed that cells will dynamically change their cytoskeletal organization in response to a
- Former group member Cole DeForest, now performing postdoctoral research under David Tirrell, published an excellent review of cutting edge bioactive hydrogel reserach titled "Bioactive Hydrogels for Regenerative Medicine" in Annual Review of
- Abby Bernard showed that pancreatic beta-cells aggregates could be formed in photopolymerized microwell devices. These cell aggregates secreted significantly more insulin per cell than dispersed cells.A.B. Bernard, C.C. Lin, and K.S. Anseth, "A
- Recent Anseth Group Alum Josh McCall showed the that proteins encapsulated in hydrogels formed by radical-mediated thiol-ene polymerization maintain significantly more activity than those encapsulated in gels formed by more traditional acrylate
- Sarah Gould showed VICs significantly upregulate alpha-SMA when plated on gels functionalized elastin and collagen mimic peptides as compared with the canonical fibronectin mimic peptide RGD. Furthermore, Sarah showed that alpha-SMA expression,
- Malar Azagarsamy demonstrated the light-mediated release of protein from PEG nanogels. He showed the release of active ALP in vitro and that nanogels enter the cell when coupled to TAT peptides.M.A. Azagarsamy, D.L. Alge, S.J.