Microscopic image of neuronsDepartment of Integrative Physiology
澳门开奖结果2023开奖记录
Boulder, CO 80309-0354
phone: 303-492-8154
fax: 303-492-0811

Research Interests

Our main focus is the neural mechanisms underlying stress-related physiology and emotional behavior with a focus on the role of serotonergic systems. Current projects address four main topics:

  1. Mechanisms of corticotropin-releasing factor (CRF) and CRF-related neuropeptides underlying control of acute and chronic anxiety states
  2. Effects on serotonergic systems, physiology, and emotional behavior by
    • glucocorticoid hormones
    • thermal signals
    • peripheral immune activation (with a focus on the microbiome-gut-brain axis)

Personnel

  • Director: Christopher A. Lowry, PhD
  • Post-doctoral Fellow: Lamya'a M. Dawud, PhD
  • Graduate Students: Tyler Akonom, Nathan Andersen, Luke Desmond, Andrew Kyo Lee, Lyanna Kessler, Saydie Sago, John Sterrett
  • Professional Research Assistants: Brandon Marquart, Lucas McCurdy, Evan Holbrook, Aislinn Concha
  • Undergraduate Research Assistants: Dennis Boateng, Sarina Borden, Matthew Alan Branney,听Zachary Alan Chafee, Aidan Clifton, Rachel Effron, Addie Horton,听Amalia Luthens,听Jeffrey听Matney, Lucie Nguyen,听Sirisai Phanekham-Mouanghane, Isaiah Shurtleff, Joni Stuart, Rose Summers, Paola Ortiz Venzor, Nolan Watts,听Caelan Wright, Richard Zabat,听Haoting Zhang

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From left to right, Back row: Kelsey Loupy, PhD; Kyo Lee; Evan Holbrook; Christopher Lowry, PhD (PI). 2nd row: Jessica Stewart; Brandon Marquart; Mathew Arnold, PhD; Ahmed Elsayed (Lab Manager); Drake Kienzle, BA. 3rd row: Madi Baca; Amalia Luthens; Stephanie Salazar; Sandra Appiah; Cristian Zambrano, PhD; Flux Caruso, PhD. Front row: Andrea Arnold; Christine Foxx, PhD; Saydie Sago, MS; Kourtney Creaney

Opportunities for Undergraduates

We are looking for enthusiastic, motivated undergraduate students who are interested in obtaining research experience. No prior laboratory research experience or coursework is required.听For more information, contact Prof. Christopher Lowry (christopher.lowry@colorado.edu)

Recent Publications

For a complete听list of publications,听.

  • Postolache TT, Akram听F, Lee听EE, 尝辞飞谤测听颁础, Stiller听JW, Brenner LA, Streeten听EA, Turecki听G,听Dwivedi听Y. Increased brain vitamin D receptor expression and decreased expression of cathelicidin antimicrobial peptide in individuals who died by suicide.听闯听笔蝉测肠丑颈补迟谤听搁别蝉.听PMID: 32213352

  • Postolache听TT, Wadhawan听A, Can听A, Lowry CA, Woodbury听M, Makkar听H, Hoisington听AJ, Scott听AJ, Potocki听E, Benros听ME,听Stiller听JW.听Inflammation in Traumatic Brain Injury.听J听Alzheimers Dis. PMID: 32176646听

  • Bernabe听CS, Caliman听IF, Truitt听WA, Molosh听AI, 尝辞飞谤测听颁础, Hay-Schmidt听A, Shekhar听A,听Johnson听PL. Using loss- and gain-of-function approaches to target amygdala-projecting serotonergic neurons in the dorsal raphe nucleus that enhance anxiety-related and conditioned fear behaviors.听J Psychopharmacol.听PMID: 32153226

  • Hagerty SL, Hutchison KE, Lowry CA, Bryan AD. An empirically derived method for measuring human gut microbiome alpha diversity: Demonstrated utility in predicting health-related outcomes among a human clinical sample.听PLoS One.听PMID: 32119675

  • Bowers听SJ, Vargas听F, Gonz谩lez听A, He听S, Jiang听P, Dorrestein听PC, Knight听R, Wright KP听Jr, 尝辞飞谤测听颁础, Fleshner听M, Vitaterna听MH,听Turek听FW. Repeated sleep disruption in mice leads to persistent shifts in the fecal microbiome and metabolome.听PloS One.听PMID: 32078624

  • Akram听F, Gragnoli听C, Raheja UK, Snitker听S, Lowry CA, Stearns-Yoder听KA, Hoisington听AJ, Brenner听LA, Saunders听E, Stiller听JW, Ryan听KA, Rohan听KJ, Mitchell听BD,听Postolache听TT. Seasonal affective disorder and seasonal changes in weight and sleep duration are inversely associated with plasma adiponectin levels.听J听Psychiatr Res. PMID: 31981963

  • Wadhawan A, Reynolds MA, Makkar H, Scott AJ, Potocki E, Hoisington AJ, Brenner LA, Dagdag A,听Lowry CA, Dwivedi Y, Postolache TT. Periodontal pathogens and neuropsychiatric health.听Curr Top Med Chem.听PMID: 31981963

  • Amoroso M, B枚ttcher A,听Lowry CA, Langgartner D, Reber SO. Subcutaneous听Mycobacterium vaccae听promotes resilience in a mouse model of chronic psychosocial stress when administered prior to or during psychosocial stress.听Brain Behav Immun.听PMID: 31887415

  • Prescott SL, Hancock T, Bland J, van den BOsch M, Jansson JK, Johnson CC, Kondo M, Katz D, Kort R, Kozyrskyj A, Logan AC,听Lowry CA, Nanan R, Poland B, Robinson J, Schroeck N, Sinkkonen A, Springmann M, Wright RO, Wegienka G.听Int J Environ Res Public Health. PMID: 31694316

  • Akram F, Jennings TB, Stiller JW,听Lowry CA, Postolache TT. Mood Worsening on Days with High Pollen Counts is associated with a Summer Pattern of Seasonality.听Pteridines.听PMID: 31631951

  • Duffy AR, O'Connell JR, Pavlovich M, Ryan KA,听Lowry CA, Daue M, Raheja UK, Brenner LA, Markon AO, Punzalan CM, Dagdag A, Hill DE, Pollin TI, Seyfang A, Groer MW, Mitchell BD, Postolache TT.听Toxoplasma gondii听Serointensity and Seropositivity: Heritability and Household-Related Associations in the Old Order Amish.听Int J Environ Res Public Health.听PMID: 31623376

  • Arnold MR, Greenwood BN, McArthur JA, Clark PJ, Fleshner M,听Lowry CA. Effects of repeated voluntary or forced exercise on brainstem serotonergic systems in rats.听Behav Brain Res.听PMID: 31525404

  • Flux MC,听Lowry CA.听Finding intestinal fortitude: Integrating the microbiome into a holistic view of depression mechanisms, treatment, and resilience.听Neurobiol Dis.听PMID: 31454550

  • Donner NC, Davies SM, Fitz SD, Kienzle DM, Shekhar A, Lowry CA. Crh receptor priming in the bed nucleus of the stria terminalis (BNST) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety.听Prog Neuropsychopharmacol Biol Psychiatry.听PMID: 31415826

  • Lieb MW, Weidner M, Arnold MR, Loupy KM, Nguyen KT, Hassell JE Jr, Schnabel KS, Kern R, Day HEW, Lesch KP, Waider J,听Lowry CA. Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice. Behav Brain Res.听PMID: 31319134